Background: Perianal manifestations of Crohn’s disease
(CD) are common, with fistulas being the most prevalent and challenging to manage.
Objective: The aim of this articles was to describe and explain how Perianal fistulizing
Crohn’s disease significantly impacts patients’ quality of life and
poses a therapeutic challenge for clinicians. Methods: The author used published papers
deposited in index databases PubMed Central, Scopus, HINARY etc. rergarding Surgical
Management of Perianal Crohn’s Disease: Current Management requires a
multidisciplinary and multimodal approach, integrating both medical and surgical
interventions tailored to disease severity and fistula complexity. Results and
Discussion: Despite advancements in therapy, the majority of patients require multiple
interventions due to high rates of primary non-healing, surgical morbidity, and
recurrence..Medical treatment primarily includes biologics, particularly anti-TNF agents
such as infliximab and adalimumab, which have demonstrated efficacy in fistula closure
and symptom control. Surgical approaches remain critical with various degrees of
success. Conclusion: Despite the availability of multiple therapeutic options, Perianal
fistulizing Crohn’s disease remains a complex condition with ongoing challenges
in achieving sustained remission. Future research should focus on novel treatment
strategies and optimizing individualized patient care.
[Acta Inform Med 2024; 32(3.000): 214-219]

Crohn’s disease, Perianal Crohn’s disease, Perianal fistula, medical and surgical management